Abstract: This paper took vibrio as a model of disease, summarized the impact of climate change on marine disease.We proposed that surface seawater temperature was the most important determination of climate change to marine disease.Based on this, the main mechanisms of how climate change infecting marine vibrio illness were discussed as followed:The first one was several virulence factors of vibrio would up-regulate owing to ocean warming, then followed by their pathogenicity increase.The second one was when ocean warming occurred, the temporal and spatial distribution of vibrio expanded, their outbreak peaks advanced, and the infecting time prolonged.The third one was indirect effect, the mechanism was altering the distribution scale of vibrio hosts in the aquatic environment, therefore, the distribution scale of vibrio expanded consequently.The fourth one was due to the sea level rising, seawater intrusion happened.The result was the salinity of inland waters increased, which produced the enlargement of vibrio optimal distribution scale.On the contrary, because of climate change, the more frequent high rainfall happened, the salinity of inland waters would decrease, the result was same as above.The last one was the host regulated a series of metabolisms in order to reply ocean warming, then their susceptibility to vibrio followed.Basic on the review of these former reports, we put forward several future suggestions about this research field, looking forward to provide a valuable reference for the prevention and regulation of vibrio disease in marine.