Abstract: In the past decade,ocean acidification has become a new challenge for the world's oceans.Ocean acidification will not only affect ocean carbon chemistry,nutrients,trace elements and other geochemical characteristics,but also affect ocean microbes,plankton,a variety of large animals and the whole marine ecosystem; biological and geochemical systems in different regions presented different responses to acidification; the same creature may present very different responses to acidification at different stages of life; the impacts that acidification bring to the ocean were extremely complex and changeable,and there were very complicated interactions between these impacts; the natural response of marine ecosystems to acidification was the result of many biotic and abiotic factors responses independently and synergistically; the simple summary of many responses of single species or single factors cannot fully describe the influences that acidification bring to the entire ecosystem.This paper reviewed the research progress of the response of marine organisms to ocean acidification,including marine microbes,plankton,a variety of large animals; and the author pointed out some current insufficient in ocean acidification research,and put forward some new ideas and methods.