Abstract: With the rapid increasing of pollution in aquatic ecosystem in the past few decades,the toxicity mechanisms of xenobiotics on aquatic organisms,especially on aquatic fish attract serious concerns.Marine medaka and zebrafish are regarded as potential model organisms for ecotoxicological study due to their advantages on culture,physiological features and genomic information,especially for their applications in toxicoproteomics.The toxicoproteomic study of marine medaka and zebrafish not only contributes to unveiling the toxicity mechanisms of xenobiotics,but also help to screen specific proteins as biomarkers for risk assessment.In this review,we summarize the recent progresses on toxicoproteomics of marine medak and zebrafish.