Abstract: The paper investigates the spatial distribution of marine invasive species in China from the perspective of large marine ecosystems and administrative divisions. Following results are concluded: frist, marine invasive species are primarily located in the large marine ecosystem of the East China Sea, secondarily located in the South China Sea and the Yellow Sea; second, floral marine invasive species are the most, then are the fauna and microorganisms; third, most marine invasive species are located acorss the large marine ecosystems with few marine invasive species disperse in the single ecosystem; finally, the varieties of marine invasive species increase from the high latitude to the low latitude area. Human activities are the main reasons to cause the spread of marine invasive species in China. 21st century is the Ocean's century. It is important to promote the sustainable development of human being. Taking the large marine ecosystme as the important coodinates, the research about the spatial distribution and the spread of marine invasive species in China reflects its significance and practical meanings.