Abstract: Marine shellfish farming, as an important part of the national aquaculture, often suffers from severe diseases.As one of the most serious bacterial disease, the shellfish vibriosis is also restricting the shellfish aquaculture development.This paper introduces the pathogenic vibrio species and their outbreaks of marine shellfish at home and abroad.It also reviews three main vibrio species (including Vibrio parahaemolyticus, Vibrio alginolyticus, and Vibrio vulnificus) and their antibiotic resistance in marine cultured shellfish, and highlights the key environmental factors which can cause the vibriosis.What's more, the new strategy and the research direction of shellfish vibriosis were discussed and prospected in this paper.