Abstract: In order to understand the impact of human activities on the changes of wetland landscape types in the Yellow River Delta wetland and to identify the dominant human factors, this paper uses Landsat 1976, 1986, 1996, 2006, 2016 satellite data and uses landscape transfer matrix, and human activity intensity model to quantitatively monitor the wetland landscape types under the influence of human activities in the Yellow River Delta during the 40 years and assess the impact of human activities by partitioning in the study area.The results are as follows:(1) Three kinds of conversions that are greatly affected by human disturbance:natural wetlands to human-made wetlands and non-wetlands are the most, and non-wetlands to human-made wetlands are medium, and human-made wetlands to non-wetlands are the least. (2) The proportion of landscape types that have been affected by human disturbances in the study area has been increasing, and the impact rate of human activities has increased from 16.77% in the first 10 years to 52.93% in the last 10 years.Farmland farming was the main human activity factor affecting the change of landscape types from 1976 to 2006.Between 2006 and 2016, the distribution of changes in natural wetlands area affected by various human activities is relatively balanced, and the proportion of transfer to reservoirs ponds is 34%.Farmland reclamation was the main influence in 1976-2016. (3) The human activity intensity model is applicable to the calculation of human activity intensity in the Yellow River Delta wetland.Between 1976 and 2016, severe disturbances were mainly concentrated in coastal areas, undisturbed and interference weakening areas were mainly concentrated in nature reserves.The results are in good agreement with the actual field survey results.The results of the study can provide a useful reference for the relevant departments to protect, manage and rehabilitate wetlands in the Yellow River Delta.