Abstract: The treatment of emerging pollutants is a major national demand, and the ocean is an important sink of the emerging pollutants. Once emerging pollutants enter the marine environment, they would pose a threat to the survival of marine organisms, especially to the marine mammals. Physiologically based toxicokinetic (PBTK) model can correlate environmental concentration of emerging pollutants with in vivo concentration. It can quantitatively describe the absorption, distribution, metabolism and excretion (ADME) process of emerging pollutants in the marine mammals, and predict the accumulation trend in target tissues, thus contributing to risk assessment for the marine ecosystem. In this study, the construction methods of the PBTK model and the research progress of the PBTK models are summarized, and the future development and application of the models are proposed.