Abstract: Desalination seawater is an important source for supplementing fresh water, its water quality is high, but the pH, alkalinity and hardness of desalination seawater are very low. Desalination seawater is corrosive due to these characteristics, which will cause damage to the pipe network if it directly brought into the urban water supply system without treatment. Therefore, this review systematically introduce the desalination of risk prevention and control technology principle, applicable conditions and development present situation from the three aspects of the pipe selection, pipe anticorrosion and desalination plant post-processing method (additive agent, dissolving ore, blending, adding magnesium method). This review can provide useful reference for the large-scale application of the desalination in the future.