Abstract: To find out the distribution characteristics of lipophilic phycotoxins (LPs) in shellfish from coastal areas of Guangdong Province, shellfish samples collected over the course of two years (November 2013 to October 2015) from Shantou Nan'ao, Shanwei, Shenzhen Dapeng Bay, Zhuhai and Yangjiang Zhapo sea areas were tested for LPs by HPLC-MS/MS.The results showed that a total of five LPs of OA, AZAs, GYM, YTXs and PTXs were detected in 174 samples of 43 shellfish species.These LPs widely distributed in coastal areas of Guangdong province, but the toxin contents in samples were all under the level of sea food safe threshold.LPs in shellfish varied in different regions, seasons and species.In terms of geographical distribution, the highest contents and detection rate of OA, AZAs and YTXs in shellfish were detected in Shantou Nan'ao.In seasonal distribution, the highest detection rate of OA in shellfish were detected in autumn.The highest contents and detection rate of PTXs in shellfish were detected in spring.In the same sea area, the LPs contents and detection rate also varied in different shellfish species.